An experimental treatment, developed at UBC, that sends electrical currents through the spinal cord has improved “invisible” yet debilitating side effects for a B.C. man with a spinal cord injury.—Image: contributed

UBC research helps with spinal cord injury

Electrical implant could improve daily activities for people with spinal cord injuries: Study

An experimental treatment that sends electrical currents through the spinal cord has improved “invisible” yet debilitating side effects for a B.C. man with a spinal cord injury.

A diving accident six years ago left Isaac Darrel, of Langley, British Columbia, with a spinal cord injury. Side effects of the injury include dizziness, fluctuations in blood pressure and changes in bladder and bowel function.

Darrel made the decision to have electrodes surgically implanted over his spinal cord in 2016 to test out a treatment known as epidural stimulation in the hopes of improving some of the side effects. A case study about his experiences was published today in JAMA Neurology.

“Mobility issues or paralysis are the most visible consequences of a spinal cord injury but as a clinician, I know that many of my patients suffer from other ‘invisible’ consequences,” said Dr. Andrei Krassioukov, principal investigator of the study who worked with Darrel for a number of years as a professor of medicine at UBC and chair in rehabilitation research with ICORD, a Vancouver research centre focused on spinal cord injuries.

“Many of my patients have abnormal blood pressure and bladder, bowel and sexual dysfunctions that can be quite devastating.”

Epidural stimulation involves surgically inserting electrodes permanently above the spinal cord and then stimulating the nerve cells in the spinal cord with electrical currents. The therapeutic benefits of epidural stimulation have been well-documented for chronic back pain, but a small number of experimental trials are testing the treatment on people with spinal cord injuries.

With a remote control, Darrel uses the stimulator for up to 45 minutes each day, applying different programs to transmit electrical impulses into his spinal cord that mimic the same signals that would come from the brain. The programs are designed to stimulate specific nerves that help with various motor functions, but Darrel and Krassioukov have observed other positive changes.

Before the treatment, Darrel said he often felt light-headed, especially when he moved from his bed to his wheelchair or during exercise, and his blood pressure would drop.

“My blood pressure would tank right down into the 60s,” said Darrel, who describes feeling nauseous and like the world was spinning. “I would pass out or black out sitting in my chair sometimes. Now, since I have the implant, I’m able to turn up the stimulation enough that it makes it impossible for me to black out.”

The symptoms Darrel experienced are part of a disorder known as orthostatic hypotension, resulting from poor cardiovascular function. Since the surgery, a team of researchers at ICORD have been following Darrel’s case and running tests to determine how his cardiovascular function has changed. Using something called a tilt table, they put patients into an upright position to see if they are able to maintain their blood pressure.

“If there is no drop in arterial blood pressure, it is considered normal,” said Dr. Krassioukov. “It means the person has good control of blood vessels in their lower extremities and the abdomen.”

The stimulator has improved Darrel’s ability to control his blood pressure as well as other benefits.

“I’ve had better blood pressure, better core muscle, much improved bowel function, and basically I have more energy,” said Darrel, who noted that this means he can now sit in his wheelchair for up to eight hours, a big improvement from the two hours he could endure prior to the surgery.

The results point to the need to fully understand how this treatment could be used in clinical settings. Krassioukov and his colleagues are currently collaborating with colleagues in the U.S. on a larger trial, examining the benefits of epidural stimulation on a bigger group. They are also involved in research on a similar but non-invasive version of the treatment that involves stimulating the spinal cord with a device positioned on top of the skin at the University of California, Los Angeles.

“We see very interesting and exciting results but as a clinician-scientist, I need more robust data before I would recommend this procedure,” he said.

The research was conducted by ICORD investigators and UBC professors Christopher West and Tania Lam, postdoctoral fellows Alex Williams and Matthias Walter, graduate student Jordan Squair and Aaron Phillips, assistant professor University of Calgary. The research was funded by the Rick Hansen Institute.

To report a typo, email: edit@kelownacapnews.com.


@KelownaCapNews
newstips@kelownacapnews.com

Like us on Facebook and follow us on Twitter.

Just Posted

Okanagan Wildfires: An afternoon update on wildfires and evacuations

A Sunday afternoon look at the major wildfires impacting the Okanagan and Similkameen.

VIDEO: Sailing under the sun at the BC Games

Maple Bay in the Cowichan Valley was host to dozens of athletes sailing on small prams to planing dinghys

BC Wildfire holding steady on Okanagan Complex

Evening update on Okanagan fire situation

Wild fires blaze in the Okanagan, in your words

We have compiled a community photo album of your wildfire photos

Power couple speed into top spot at L’Alpe de Grand Blanc at Big White

The professional riders have been training all year

BC Games: Day 3 wrap and closing ceremonies

The torch in the Cowichan Valley has been extinguished as Fort St. John gets ready to host the 2020 BC Winter Games

Police confirm girl, 8 others injured in Toronto shooting; shooter dead

Paramedics said many of the victims in Danforth, including a child, were rushed to trauma centres

Why do they do it? Coaches guide kids to wins, personal bests at the BC Games

Behind the 2,300 B.C. athletes are the 450 coaches who dedicate time to help train, compete

Reel Reviews: Floundering inferno

We quote Charlie Brown: “Good grief!”

UPDATE: Five taken to hospital following one of two Coquihalla accidents

One airlifted in critical condition, four taken via ambulance in stable condition

Ottawa fails to find alternative buyer for Trans Mountain pipeline by deadline

The feds had announced it was purchasing the $4.5 billion pipeline earlier this spring

Government sets full-time salary range for Justin Trudeau’s nanny

At its top range, the order works out to a rate of $21.79 per hour, assuming a 40-hour work week

Lower Mainland teams battle for baseball gold at BC Games

Vancouver Coastal squeaked out a 3-2 win against Fraser Valley

The Northern Secwepemc te Qelmucw people signed an agreement-in-principle with the B.C. government

The signing ceremony, at the Eliza Archie Memorial School, was 25 years in the making

Most Read