Pharmacist Madeline Acquilano draws a syringe of Johnson & Johnson COVID-19 at Hartford Hospital in Hartford, Conn., Wednesday, March 3, 2021. (AP Photo/Jessica Hill)

Pharmacist Madeline Acquilano draws a syringe of Johnson & Johnson COVID-19 at Hartford Hospital in Hartford, Conn., Wednesday, March 3, 2021. (AP Photo/Jessica Hill)

What you need to know about Johnson & Johnson’s approved single-dose vaccine

The vaccine had a 72% efficacy in preventing COVID infections after 28 days in the company’s U.S. trials

Canada added a single-dose COVID-19 vaccine to its pandemic-fighting arsenal on Friday, approving Johnson & Johnson’s product a week after it was authorized in the United States.

That gives Canada four approved vaccines — Pfizer-BioNTech and Moderna inoculations were approved in December and the Oxford-AstraZeneca jab was endorsed last week— and it adds flexibility to the country’s plan to immunize the majority of its residents by September.

The U.S.-based Food and Drug Administration (FDA) approved the Johnson & Johnson vaccine for emergency use on Feb. 27.

Canada has already secured up to 38 million doses of the Johnson & Johnson vaccine through previous negotiations with the company, however it’s not expected that any will flow to Canada until at least April.

Here’s what we know about the Johnson & Johnson vaccine:

HOW EFFECTIVE IS IT?

Johnson & Johnson announced promising results from its Phase 3 clinical trials at the end of January, suggesting its vaccine reduced severe COVID-19 disease by 85 per cent, and prevented 100 per cent of COVID-related hospitalization or death.

The vaccine had a 72 per cent efficacy in preventing COVID infections after 28 days in the company’s U.S. trials. The efficacy dropped to 66 per cent when averaging in results from other global trials, including a South African study that factored in more transmissible variants of the COVID virus.

An FDA report last monthsaid the vaccine was 64 per cent effective in preventing infection in South Africa about a month after the vaccines were administered.

Pfizer and Moderna showed 95 per cent efficacy in their respective trials, but those were both tested against previous dominant strains of the virus and didn’t account for the variants that have popped up since.

Pfizer, Moderna and AstraZeneca also had zero hospitalizations and deaths in their trials.

The FDA report said the Johnson & Johnson vaccine was similarly effective across age, race and people with comorbidities. The agency added that effectiveness appeared to be lower (42.3 per cent after one month) in people over 60 with comorbidities such as diabetes or heart disease.

WHAT ARE THE BENEFITS OF THIS VACCINE?

The potential ease of distribution offered by a one-and-done shot, and its ability to be stored in a regular fridge are among its biggest strengths.

Vaccines from Pfizer, Moderna and AstraZeneca all require two doses.

Johnson & Johnson’s vaccine can be stored in a regular fridge for up to three months, the company says.

Pfizer’s vaccine initially required ultra-cold storage temperatures between -60 C and -80 C, though Health Canada said this week it could be stored in a regular freezer for up to 14 days.

Moderna’s vaccine can also be stored at regular freezer temperatures.

WHAT KIND OF VACCINE TECHNOLOGY IS USED?

Unlike the mRNA technology used in Pfizer and Moderna’s products, Johnson & Johnson is a non-replicating viral vector vaccine similar to AstraZeneca’s.

That means it uses a different harmless virus as a vector, which can’t copy itself, to give our cells the instructions they need to make the coronavirus’s spike protein.

The immune system recognizes the protein and makes antibodies, which then allow us to fend off attack from the same virus if exposed in the future.

WERE THERE ANY SIDE EFFECTS NOTED?

The FDA document said no specific safety concerns were identified in participants regardless of age, race and comorbidities.

The FDA added the most common reported side effects were headache and fatigue, followed by muscle aches, nausea and fever.

This report by The Canadian Press was first published March 5, 2021.

Melissa Couto Zuber, The Canadian Press

Coronavirus

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

The West Kelowna Warriors beat the Vernon Vipers 3-2 in BCHL action Friday, April 16, 2021. (Lisa Mazurek Photography)
West Kelowna goaltender stymies Vernon Vipers for 3-2 win

The Warriors were outshot 44-23 Friday night, but it didn’t bother Johnny Derrick

A group of youth in Kelowna's Knox Mountain Park are suspected as having violated the B.C. Wildlife Act by harassing a pair of nesting bald eagles with a drone Friday, April 16, 2021. (Conservation Officer Service photo)
Nesting bald eagles harassed by youth-piloted drone in Kelowna

Conservation Officers are hoping to hear from anyone who witnessed the Knox Mountain incident

Ben Klick is a country music singer living in Kelowna, B.C. (Contributed)
Kelowna’s Ben Klick partnering with local country music stations for annual virtual music festival fundraiser

The third annual Music Fest MS will come in the form of a Youtube livestream on May 30

The seventh annual Interior Savings Unplug and Play Family Literacy Week is scheduled for April 18 to 24. (File photo)
Annual Unplug and Play Week scheduled for April 18 to 24

Activities include making craft bags, neighbourhood hidden gems bingo, a scavenger hunt and more

A West Kelowna home was damaged in a fire that occurred overnight on Saturday, April 17. (Photo courtesy of West Kelowna Fire Rescue)
West Kelowna home damaged in overnight fire

The cause of the fire is undetermined and has been deemed unsuspicious

Flow Academy is located at 1511 Sutherland Avenue in Kelowna. (Michael Rodriguez - Capital News)
Black Press Media Weekly Roundup: Top headlines this week

Here’s a quick roundup of the stories that made headlines across the Okanagan, from April 11 to 16

Firefighters battled a burning home on farmland in the north end of Vernon Saturday, April 17, 2021. (Brendan Shykora - Morning Star)
UPDATE: Homeowner taken to hospital after Vernon home destroyed by fire

Firefighters engaged in a lengthy battle against the engulfed structure Saturday afternoon

Members of the Okanagan Screen Arts Society received a cheque for $1,500 Thursday, April 15, 2021. The funds are to help the society’s efforts as they prepare take over operation of the Vernon Towne Cinema at the end of July. (Brendan Shykora - Morning Star)
Okanagan dealership gives local cinema a lift

Vernon Watkin Motor Ford, in business for more than 100 years, donated to the theatre with nearly as long a history

Vernon Jubilee Hospital. (File photo)
COVID-19 outbreak declared over in surgical unit of Vernon hospital

The outbreak affected four staff, 10 patients and led to three deaths in just over two weeks

Pall Bearers carrying the coffin of the Duke of Edinburgh, followed by the Prince of Wales, left and Princess Anne, right, into St George’s Chapel for his funeral, at Windsor Castle, in Windsor, England, Saturday April 17, 2021. (Danny Lawson/Pool via AP)
Trudeau announces $200K donation to Duke of Edinburgh award as Prince Philip laid to rest

A tribute to the late prince’s ‘remarkable life and his selfless service,’ the Prime Minister said Saturday

Cannabis bought in British Columbia (Ashley Wadhwani/Black Press Media)
Is it time to start thinking about greener ways to package cannabis?

Packaging suppliers are still figuring eco-friendly and affordable packaging options that fit the mandates of Cannabis Regulations

B.C. homeowners are being urged to take steps to prepare for the possibility of a flood by moving equipment and other assets to higher ground. (J.R. Rardon)
‘Entire province faces risk’: B.C. citizens urged to prepare for above-average spring flooding

Larger-than-normal melting snowpack poses a threat to the province as warmer weather touches down

Vancouver-based Doubleview Gold Corp. is developing claims in an area north of Telegraph Creek that occupies an important place in Tahltan oral histories, said Chad Norman Day, president of the Tahltan Central Government. (THE CANADIAN PRESS/HO)
B.C. Indigenous nation opposes mineral exploration in culturally sensitive area

There’s “no way” the Tahltan would ever support a mine there, says Chad Norman Day, president of its central government

Stz’uminus Elder George Harris, Ladysmith Mayor Aaron Stone, and Stz’uminus Chief Roxanne Harris opened the ceremony. (Cole Schisler photo)
Symbolic red dresses rehung along B.C. highway after vandals tore them down

Leaders from Stz’uminus First Nation and the Town of Ladysmith hung new dresses on Sat. April 17

Most Read