(The Canadian Press)

Cancer trial to focus on protecting patients from COVID-19 infection

Cancer patients are at much higher risk of severe complications from COVID-19 because of chemotherapy

A national clinical trial this summer will focus on protecting cancer patients against severe COVID-19 infection by attempting to boost their compromised immune system.

Researchers from The Ottawa Hospital say they want to explore the potential of IMM-101, a preparation featuring a dead pathogen containing properties that can stimulate the “first-response arm” of the immune system.

Study lead Dr. Rebecca Auer, surgical oncologist and director of cancer research at the Ottawa Hospital, says it could help experts understand why some COVID-19 patients are relatively asymptomatic while others end up in intensive care or die.

“The difference it seems between these two different presentations has to do with how strong your innate, or your sort of non-specific, first-line defence immune system response is to the virus,” Auer said Wednesday.

“And so we’re hoping that by boosting and stimulating this innate immune response, particularly in those vulnerable patients that have a reduced immune response to begin with, we’d be able to prevent symptomatic infections and prevent serious infections.”

Cancer patients are at much higher risk of severe complications from COVID-19 because chemotherapy, cancer surgery and radiation treatments suppress innate immunity even further.

Auer points to an “urgent need” to protect them while the world waits for an effective COVID-19 vaccine, which could take another year or more to develop, test, and implement.

A successful trial could also protect cancer patients against other respiratory infections as well as the coming flu season, says Auer, noting the threat of illness is a fairly big problem for those undergoing treatment.

“A study demonstrated that about 13 to 15 per cent of cancer patients will have to delay or stop their treatment because of influenza during the average flu season,” she says.

“And also cancer patients don’t respond as well to the influenza vaccine every year because their immune system isn’t as strong. So we think that the IMM-101 may in itself be able to help prevent symptomatic influenza infections.”

Auer says IMM-101 has also been tested elsewhere for its anti-cancer properties and that, too, will be examined in this trial, although it’s not the primary objective.

The researchers say the bacteria, Mycobacterium obuense, is safe to use in cancer patients because it has been killed by heat.

The Canadian study will recruit 1,500 patients currently receiving cancer treatment, and participants will be randomly assigned to receive either regular care, or regular care plus IMM-101.

Auer says the treatment would be administered as an injection in the arm, to be followed by two more booster shots.

Researchers will follow patients for a year, watching for any respiratory infections and monitoring whether the treatment works and how long it lasts.

The trials will take place in eight centres located in Ontario, British Columbia and Quebec.

Researchers say people interested in participating should speak with their cancer specialist.

Researchers from the Ottawa Hospital came up with the idea and worked with the Canadian Cancer Trials Group at Queen’s University to design the trial.

Dr. Chris O’Callaghan of the Queen’s University group notes cancer patients are also at greater risk of COVID-19 infection because they require regular medical care, making it difficult to adhere fully to public health guidelines.

“These patients are unable to practice social isolation due to the need to regularly attend hospital to receive critically important cancer treatment,” says O’Callaghan, who will oversee the trial.

Auer says a successful trial of IMM-101 could also suggest usefulness in treating any patient with a reduced innate immune system, such as older patients with chronic illness.

She notes that the tuberculosis vaccine known as BCG — which uses a similar formulation to IMM-101 but uses live bacteria instead of dead bacteria — is being tested around the world to see if it can boost the immunity of health-care workers exposed to COVID-19.

Funding and in-kind support, valued at $2.8 million, comes from the Canadian Cancer Society, BioCanRx, the Ontario Institute for Cancer Research, The Ottawa Hospital Foundation, The Ottawa Hospital Academic Medical Organization, ATGen Canada/NKMax, and Immodulon Therapeutics, the manufacturer of IMM-101.

The Canadian Press

Like us on Facebook and follow us on Twitter.

Want to support local journalism? Make a donation here.

Coronavirus

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

Central Okanagan Public Schools is making a bid to secure a total of $18 million in funding to provide new child care facilities at six Kelowna and West Kelowna public school sites. (Contributed)
Seeking to expand Kelowna, West Kelowna child care resources

Central Okanagan Public Schools to apply for $18 million in provincial funding to build new child care facilities at six school sites

An artist’s rendering of the proposed development that would replace the Hiawatha RV Park in Kelowna. (Contributed)
Eviction notice leaves Kelowna trailer park resident fearing homelessness

44 mobile home units at Hiawatha RV Park were served an eviction notice yesterday, making room for new development

Leighton Allen Labute faces charges of animal abuse and allegedly has a string of social media accounts depicting disturbing content.
Accused Kelowna hamster killer facing new charge for publishing video online

Leighton Allen Labute, 21, is also charged with killing and causing unnecessary suffering to one or more hamsters

test tube with the blood test is on the table next to the documents. Positive test for coronavirus covid-19. The concept of fighting a dangerous Chinese disease.
Interior Health records third COVID-19 death

A new community outbreak was reported at Okanagan Men’s Centre in Lake Country

(RCMP)
RCMP searching for missing Kelowna man

Nathan David Copp was last seen this morning, Oct. 28

Provincial health officer Dr. Bonnie Henry updates the COVID-19 situation, B.C. legislature, Oct. 26, 2020. (B.C. government)
B.C.’s COVID-19 case count jumps by 287, another senior home outbreak

Two more deaths recorded, community outbreak in Okanagan

An untitled Emily Carr painting of Finlayson Point was donated to the Art Gallery of Greater Victoria by brothers Ian and Andrew Burchett. The painting had been in their family for several decades. (Courtesy of the Art Gallery of Greater Victoria)
Never before seen painting by famed B.C. artist Emily Carr gifted to Victoria gallery

Painting among several donated to Art Gallery of Greater Victoria

The B.C. Centre for Disease control is telling people to keep an eye out for the poisonous death cap mushroom, which thrives in fall weather conditions. (Paul Kroeger/BCCDC)
Highly poisonous death cap mushroom discovered in Comox

This marks first discovery on Vancouver Island outside Greater Victoria area

100 Mile Conservation officer Joel Kline gingerly holds an injured but very much alive bald eagle after extracting him from a motorist’s minivan. (Photo submitted)
Rescued bald eagle that came to life in B.C. man’s car had lead poisoning

Bird is on medication and recovering in rehab centre

Is it time to start thinking about greener ways to package cannabis?

Packaging suppliers are still figuring eco-friendly and affordable packaging options that fit the mandates of Cannabis Regulations

In May 2019, Brennan Joel Metlewsky and Jordan Robert Kupser were charged with attempted murder, robbery and aggravated assault stemming from an incident that took place in Vernon in 2017. (Facebook photo)
Attempted murder charges dropped for pair accused in Vernon stabbing

Brennan Metlewsky and Jordan Kupser will appear in Supreme Court to set a new trial date

Join Black Press Media and Do Some Good

Pay it Forward program supports local businesses in their community giving

Eric Termuende and the Emily Dahl Foundation are presenting a virtual ‘fireside conversation’ on modern happiness from the stage of the Powerhouse Theatre in Vernon Nov. 3, 2020, at 7 p.m. (YouTube)
Mental health advocate joins happiness chat in North Okanagan

Versed public speaker teams up with Emily Dahl Foundation to equip virtual guests with tools to live a happier life

A boat moored at Turtle Bay Marina was reported stolen Oct. 1 and remains under investigation. (Contributed)
North Okanagan crimes remain unsolved

Boat stolen from marina, theft of siding and vehicle break and enter

Most Read