This undated photo provided by the Oregon Health and Science University in March 2019 shows a baby monkey named Grady, at two weeks old, born from an experimental technology that aims to help young boys undergoing cancer treatment preserve their future fertility. Scientists froze testicular tissue from a monkey that had not yet reached puberty, and later thawed it to produce sperm used for Grady’s conception. (OHSU via AP)

This undated photo provided by the Oregon Health and Science University in March 2019 shows a baby monkey named Grady, at two weeks old, born from an experimental technology that aims to help young boys undergoing cancer treatment preserve their future fertility. Scientists froze testicular tissue from a monkey that had not yet reached puberty, and later thawed it to produce sperm used for Grady’s conception. (OHSU via AP)

Monkey birth a step to saving fertility of boys with cancer

The technique worked well enough that human testing should begin in the next few years

Scientists are closing in on a way to help young boys undergoing cancer treatment preserve their future fertility — and the proof is the first monkey born from the experimental technology.

More and more people are surviving childhood cancer, but nearly 1 in 3 will be left infertile from the chemotherapy or radiation that helped save their life.

When young adults are diagnosed with cancer, they can freeze sperm, eggs or embryos ahead of treatment. But children diagnosed before puberty can’t do that because they’re not yet producing mature eggs or sperm.

“Fertility issues for kids with cancer were ignored” for years, said University of Pittsburgh reproductive scientist Kyle Orwig. “Many of us dream of growing up and having our own families. We hope our research will help these young patients to do that.”

Orwig’s team reported a key advance Thursday: First, they froze a bit of testicular tissue from a monkey that hadn’t yet reached puberty. Later, they used it to produce sperm that, through a monkey version of IVF, led to the birth of a healthy female monkey named Grady.

The technique worked well enough that human testing should begin in the next few years, Orwig said.

“It’s a huge step forward” that should give hope to families, said Susan Taymans of the National Institute of Child Health and Human Development, which helped fund the research published in the journal Science. “It’s not like science fiction. It’s something that seems pretty attainable.”

University of Pittsburgh Medical Center and a handful of other hospitals already freeze immature testicular tissue from young cancer patients, in hopes of knowing how to use it once they’re grown and ready to have their own children.

Boys are born with stem cells inside little tubes in the testes, cells that start producing sperm after puberty’s testosterone jolt. Orwig’s goal: Keep sperm-producing stem cells safe from cancer treatment by freezing small pieces of testicular tissue, and using them to restore fertility later in life.

How? Enter the monkey research.

Orwig’s team froze tissue from young male monkeys, and then sterilized them. Once the monkeys approached puberty, the researchers thawed those tissue samples and gave them back to the original animal — implanting them just under the skin.

“We’re not hooking it up to the normal plumbing,” Orwig cautioned.

READ MORE: New B.C. pilot to probe how blood tests might improve cancer treatment

Boosted by hormones, the little pieces of tissue grew. Months later, the researchers removed them. Sure enough, inside was sperm they could collect and freeze.

Colleagues at the Oregon National Primate Research Center injected some of that sperm into eggs from female monkeys and implanted the resulting embryos. Last April, Grady was born, and “she plays and behaves just like every other monkey that was grown the normal way,” Orwig said.

If the technique sounds a little bizarre, it’s similar to a female option.

Girls’ eggs are in an immature state before puberty. Researchers have removed and frozen strips of ovarian tissue harbouring egg follicles from young women before cancer treatment, in hopes that when transplanted back later the immature eggs would resume development. It’s considered experimental even for young adults but some births have been reported. Now some hospitals bank ovarian tissue from girls, too.

Surgery involving the boys’ testicular tissue is less invasive, noted Orwig, who also is researching ways to reinsert sperm-producing stem cells where they belong rather than the more roundabout technique.

The new research shows “immature testicular tissue may become an option” to preserve boys’ fertility, Nina Neuhaus and Stefan Schlatt of the Center of Reproductive Medicine and Andrology in Muenster, Germany, wrote in an accompanying editorial.

Meanwhile, “it’s important for parents to know about this,” said Christine Hanlon of Holiday, Florida, who took her son Dylan to Pittsburgh to have his tissue stored when he was newly diagnosed with Ewing’s sarcoma at age 9.

Today Dylan is a healthy teen, and no one knows if he’ll ever need the stored tissue, one of more than 200 samples Orwig’s study has preserved. But Hanlon was thrilled to learn the research is moving along, just in case.

“You lose part of your childhood in cancer treatment,” Hanlon said. “If there was a chance I could help him have normalcy in his future, with the potential of having a family if that’s what he decided to do, I wanted to be able to.”

Lauran Neergaard, The Associated Press

Like us on Facebook and follow us on Twitter.

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

B.C. wineries are open for indoor tasting despite new provincial health regulations. Photo- 
50th Parallel Winery, Instagram.
Indoor wine tastings still allowed in B.C., not considered a ‘social gathering’

“Tasting is really just part of the retail experience. The analogy I use is you wouldn’t buy a pair of pants without trying them on.”

The District of Peachland seen from the skies over Highway 97. (Contributed)
Peachland council supports RDCO emergency operations grant application

The district’s emergency operations are managed regionally

Elijah Beauregard, 16, was stabbed in downtown Kelowna on June 27, 2019. He died of his wounds three days later in hospital. His family is raising money to put a memorial bench at his favourite skatepark in Penticton.
Young woman charged in stabbing death of Penticton teen pleads guilty

The teen, who can’t be named, will appear in Kelowna Supreme Court Tuesday

A crane stands in the middle of a fire-ravaged Glenmore Road construction site on Thursday, April 8. (Aaron Hemens - Capital News)
Evacuation order remains in effect around burned Glenmore Road construction site

Assessment of potentially risky crane to take place this afternoon

Kelowna-based company GTEC Cannabis Co. has paid off $6 million in debts. (GTEC Cannabis Co. - Facebook)
Kelowna cannabis company pays off $6M debt

GTEC Cannabis Co. is now one of the few debt-free companies in the sector

Burnaby MLA Raj Chouhan presides as Speaker of the B.C. legislature, which opened it spring session April 12 with a speech from the throne. THE CANADIAN PRESS
B.C. NDP promises more health care spending, business support in 2021 budget

John Horgan government to ‘carefully return to balanced budgets’

The Red Pill Rapper performs to the crowd gathered for the Rally For Food Security at Blackburn Park on Saturday, April 10, 2021. (Kristal Burgess Photography)
The Red Pill Rapper performs to the crowd gathered for the Rally For Food Security at Blackburn Park on Saturday, April 10, 2021. (Kristal Burgess Photography)
Suspicion of ‘fake news media’ makes rally uncomfortable for Salmon Arm event photographer

More than 300 people counted at city park for ‘Rally For Food Security’

A lady wears a sticker given out after receiving a COVID-19 vaccine at a clinic in Richmond, B.C., Saturday, April 10, 2021. THE CANADIAN PRESS
B.C.’s COVID-19 case count slows after last week’s peak

3,219 new cases since Friday, 18 additional deaths

North Cowichan councillor Tek Manhas did not violate the municipality’s code of conduct by posting a sexist meme on Facebook, council concludes. (File photo)
B.C. municipality to take no action against councillor who posted sexist meme

Tek Manhas’s meme doesn’t violate North Cowichan council’s code of conduct, municipality concludes

The former Summerland Asset Development Initiative building on Prairie Valley Road in Summerland was suggested as the site for a temporary transitional housing facility for the community. However, Summerland council has rejected this proposal. (John Arendt - Summerland Review)
Summerland council rejects transitional housing facility

Concerns raised about short timeline and condition of municipally-owned building

Penticton Vees continue their winning streak carrying a 5-0 win title as of Sunday night's hockey action. (Cherie Morgan/Cherie Morgan Photography)
Penticton Vees continue winning streak

Sunday night’s 6-1 win has them with five in a row since the start of the season

Cannabis bought in British Columbia (Ashley Wadhwani/Black Press Media)
Is it time to start thinking about greener ways to package cannabis?

Packaging suppliers are still figuring eco-friendly and affordable packaging options that fit the mandates of Cannabis Regulations

A sign on a shop window indicates the store is closed in Ottawa, Monday March 23, 2020. The Canadian Federation of Independent Business is raising its estimate for the number of businesses that are considering the possibility of closing permanently. THE CANADIAN PRESS/Adrian Wyld
Small business struggling amid COVID-19 pandemic looks for aid in Liberals’ budget

President Dan Kelly said it is crucial to maintain programs to help businesses to the other side of the pandemic

The National Security and Intelligence Committee of Parliamentarians says that includes attempts to steal Canadian research on COVID-19 and vaccines, and sow misinformation. (AP Photo/Esteban Felix)
Intelligence committee warns China, Russia targeting Canadian COVID-19 research

Committee also found that the terrorist threat to Canada has shifted since its last such assessment

Most Read